Analysis of the qualitative composition of matrix metalloproteinases in the pathogenesis of obesity induced by a high-fat diet in rats

The problem of obesity in modern life is becoming more actual and a serious social risk for human life. This common despite professional affiliation, location, age gender. Obesity associated with an increase growth adipose tissue. Today isn't studied only as excessive accumulation fat the body, but chronic multivariate disease number metabolic, oncological, cardiological other complications. Although lot research studies regulation intracellular processes adipogenesis, however information about molecular mechanisms remodeling extracellular matrix during mass limited. Matrix metalloproteinases (MMPs) can plasticity matrix, thereby providing tissue / or adipocyte hypertrophy, play additional role obesity, supporting differentiation progenitor cells. Our aimed at characterization enzymatic activitiesof MMPs rats obesity. We found that active enzymes weight > 100 kDa were development which may result from formation homodimers these pathological conditions.Also activities MMP-2, -9 Future activity rat's adipocytes tissues will improve understanding biochemical under conditions this pathology new approaches to diagnosis treatment principles.